Wentworth-Douglass Hospital
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Definition:

Gilbert's disease is a common disorder passed down through families.It affects the way bilirubin is processed by the liver, and causes jaundice .



Alternative Names:

Icterus intermittens juvenilis; Low-grade chronic hyperbilirubinemia; Familial non-hemolytic-non-obstructive jaundice; Constitutional liver dysfunction; Unconjugated benign bilirubinemia



Causes, incidence, and risk factors:

Gilbert's disease affects up to 10% of people in some Caucasian populations. The condition is usually noncancerous (benign ).



Symptoms:
  • Fatigue
  • Yellowing of the skin and whites of the eyes (mild jaundice)

Note: Jaundice typically appears during times of exertion, stress, not eating, and infection.



Signs and tests:

An indirect bilirubin blood test shows changes that occur with Gilbert's disease.



Treatment:

No treatment is necessary for Gilbert's disease.



Support Groups:



Expectations (prognosis):

Jaundice may come and go throughout your life, especially during illnesses such as colds. However, it usually does not cause health problems.



Complications:

There are no known complications.



Calling your health care provider:

Call your health care provider if you have jaundice or persistent abdominal pain .



Prevention:

There is no proven prevention.



References:

Berk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 150.




Review Date: 4/23/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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Wentworth-Douglass Hospital
789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100