Wentworth-Douglass Hospital
(603) 742-5252
Decrease (-) Restore Default Increase (+) font size
Physicians
myWDconnect Patient Portal
Pay Your Bill Online
Pricing Estimates
Financial Assistance
Health Library
Health Insurance Marketplace
Interpreter and Communication Services
Surgery Preparation
Medical Records
Accountable Care Organization
Advance Directives
Clinical Research & Trials
Food and Nutrition Services
Back to Health Library   Print This Page Print    Email to a Friend Email

Antibodies
Antibodies


Definition:

Immunodeficiency disorders occur when the body's immune response is reduced or absent.

See also: Autoimmune disorders



Alternative Names:

Immunosuppression



Causes, incidence, and risk factors:

The immune system is made up of lymphoid tissue in the body, which includes the bone marrow, lymph nodes, thymus, tonsils, and parts of the spleen and gastrointestinal tract.

The immune system helps protect the body from harmful substances called antigens . Examples of antigens include bacteria, viruses, toxins , cancer cells, and foreign blood or tissues from another person or species.

When the immune system detects an antigen, it responds by producing antibodies that destroy the harmful substances. The immune system response also involves a process called phagocytosis. During this process, certain white blood cells swallow and destroy bacteria and other foreign substances.

Immune system disorders occur when the immune system does not fight tumors or harmful substances as it should. The immune response may be overactive or underactive.

Immunodeficiency disorders may affect any part of the immune system. Most commonly, such a condition occurs when specialized white blood cells called T or B lymphocytes (or both) do not work as well as they should, or when your body doesn't produce enough antibodies.

Inherited immunodeficiency disorders that affect B cells include:

  • Hypogammaglobulinemia, which usually causes mild to moderate respiratory infections
  • Agammaglobulinemia , which results in frequent severe infections and is often deadly

Inherited immunodeficiency disorders that affect T cells may cause increased susceptibility to fungi, resulting in recurring Candida (yeast) infections. Inherited combined immunodeficiency affects both T cells and B cells. It may be deadly within the first year of life if it isn't treated early.

People are said to be immunosuppressed when they have an immunodeficiency disorder due to medicines that affect the immune system (such as corticosteroids). Immunosuppression is also a common side effect of chemotherapy.

Acquired immunodeficiency may be a complication of diseases such as HIV infection and AIDS . Malnutrition, particularly with lack of protein, and many cancers may also cause immunodeficiency.

People who have had their spleen removed are at higher risk for infection by certain bacteria that the spleen would normally help fight. Patients with diabetes are also at higher risk for certain infections.

Increasing age reduces the effectiveness of the immune system to some degree. Immune system tissues (particularly lymphoid tissue such as the thymus) shrink, and the number and activity of white blood cells drop.

The following conditions and diseases can result in an immunodeficiency disorder:

  • Ataxia-telangiectasia
  • Chediak-Higashi syndrome
  • Combined immunodeficiency disease
  • Complement deficiencies
  • DiGeorge syndrome
  • Hypogammaglobulinemia
  • Job syndrome
  • Leukocyte adhesion defects
  • Panhypogammaglobulinemia
    • Bruton disease
    • Congenital agammaglobulinemia
  • Selective deficiency of IgA
  • Wiscott-Aldrich syndrome


Symptoms:

The symptoms vary with the specific disorder.



Signs and tests:

Your doctor might think you have an immunodeficiency disorder is present if you have:

  • Persistent, recurrent infections; or
  • Severe infection by microorganisms that do not usually cause severe infection

Other signs include:

  • Poor response to treatment
  • Delayed or incomplete recovery from illness
  • Certain types of cancers (such as Kaposi's sarcoma or non-Hodgkin's lymphoma)
  • Certain infections (including some forms of pneumonia or recurrent fungal yeast infections)

Tests used to help diagnose an immunodeficiency disorder may include:



Treatment:

The goal of treatment is to prevent infections and treat any disease and infections that do develop.

If you have a weakened immune system, you should avoid contact with persons who have infections or contagious disorders. This may include avoiding people who have been vaccinated with live virus vaccines within the past two weeks.

If you develop an infection, your doctor will treat you aggressively. This may involve long-term use of antibiotic or antifungal medications and preventive (prophylactic) treatments.

Interferon is used to treat viral infections and some types of cancer. It is an immunostimulant drug, a medicine that makes the immune system work better.

Persons with HIV and AIDS may take combinations of drugs to reduce the amount of virus in their immune systems, thus improving their immunity.

Patients undergoing a planned splenectomy should be vaccinated two weeks prior to the surgery against encapsulated organisms such as Streptococcus pneumonia and Hemophilus influenzae.

Bone marrow transplant may be used to treat certain immunodeficiency conditions.

Passive immunity (administration of antibodies produced by another person or animal) may occasionally be recommended to prevent illness after exposure to a microorganism.

Patients with hypogammaglobulinemia are treated with periodic immunoglobulin infusions through a vein to raise blood immunoglobulin levels towards the normal range.



Support Groups:



Expectations (prognosis):

Some immunodeficiency disorders are mild and result in occasional illness. Others are severe and may be fatal. Immunosuppression that results from medications is often reversible once the medication is stopped.



Complications:
  • Disease development
  • Frequent or persistent illness
  • Increased risk for certain cancers or tumors
  • Opportunistic infections


Calling your health care provider:

Call your health care provider immediately if you are on chemotherapy or corticosteroids (such as prednisone, Medrol, or Decadron) and you develop a fever greater than 100.5 degrees Fahrenheit or have cough with shortness of breath.

Go to the emergency room if you have a stiff neck and headache with the fever.

Contact your health care provider if you have recurrent yeast infections or oral thrush.



Prevention:

There is no known prevention for congenital immunodeficiency disorders. Safe sex practices and avoiding the sharing of body fluids may help to prevent HIV infection and AIDS. Good nutrition may prevent acquired immunodeficiency caused by malnutrition.



References:

Bonilla FA, Bernstein IL, Khan DA, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005;94:S1-S63.




Review Date: 5/2/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Stuart I. Henochowicz, MD, FACP, Associate Clinical Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, Georgetown University Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Find What You Need

Events
Careers
Foundation
About Us
Contact
Directions
News
Social Media Agreement
Joint Notice
Web Privacy Policy
WDH Staff Portal

Centers & Services

Cancer Center
Cardiovascular Care
Joint Replacement
Women & Children's
Physician Offices
Other Services

Conditions & Treatments

Health Library

Support Services

Support Groups
Care-Van
Dental Center
Social Work
Food & Nutrition
Integrative Wellness
Spiritual Care
Concerns & Grievances
Homecare and Hospice

For Patients

Pay Your Bill Online
Pricing Estimates
Financial Assistance
Interpreter Services
Surgery Preparation
Medical Record Request
Advance Directives
Clinical Research & Trials

For Healthcare Professionals

Work and Life
Financial Well-Being
Career and Growth

The Wentworth-Douglass Health System includes:

 

Address

Wentworth-Douglass Hospital
789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100