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Central nervous system
Central nervous system


Definition:

Cryptococcal meningitis is a fungal infection of the membranes covering the brain and spinal cord (meninges).

See also:



Alternative Names:

Cryptococcal meningitis



Causes, incidence, and risk factors:

Cryptococcal meningitis is caused by the fungus Cryptococcus neoformans. This fungus is found in soil around the world.

Cryptococcal meningitis most often affects people with compromised immune systems. Risk factors include:

It occurs in 5 out of 1 million people.



Symptoms:

Signs and tests:

In order to diagnose cryptococcal meningitis, a lumbar puncture (spinal tap) must be performed. This test involves taking a sample of fluid from the spinal column (called cerebrospinal fluid or CSF). The following tests on the CSF allow the health care provider to diagnose cryptococcal meningitis:

  • CSF culture
  • CSF stains
  • CSF test for cryptococcus antigen
  • Serum cryptococcal antigen blood test

If you are diagnosed with cryptococcal meningitis, your doctor will also recommend:



Treatment:

Antifungal medications are used to treat this form of meningitis. Intravenous therapy with amphotericin B is the most common treatment. It is often combined with an oral medication, 5-flucytosine. An oral medication, fluconazole, in high doses may also be effective against this infection.



Support Groups:



Expectations (prognosis):

People with AIDS need long-term treatment with medication, to prevent the infection from coming back.



Complications:

Obstructive hydrocephalus is a complication. This occurs when the infection disrupts the normal movement of CSF around the brain and spinal cord. A tube called a shunt, which moves CSF around the obstruction, can relieve the pressure.

Amphotericin B can have side effects, including chills and stiffness, and sometimes kidney damage.



Calling your health care provider:

Call the local emergency number (such as 911) or go to the emergency room if you have symptoms of meningitis, or if you are being treated for meningitis and your symptoms get worse.

Go to the emergency room as quickly as possible if you have:

  • Changes in your senses or mental state
  • Difficulty breathing or swallowing
  • Numbness
  • Paralysis


Prevention:



References:

Kauffman CA. Cryptococcosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 357.




Review Date: 9/28/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, PhD, MD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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Wentworth-Douglass Hospital
789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100