Wentworth-Douglass Hospital
(603) 742-5252
Decrease (-) Restore Default Increase (+) font size
Physicians
Site Search

Blood test
Blood test


Definition:

The CPK isoenzymes test measures the different forms of creatine phosphokinase (CPK) in the blood. CPK is an enzyme found mainly in the heart, brain, and skeletal muscle.

See also: Creatine phosphokinase test



Alternative Names:

Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes



How the test is performed:

Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.

Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.

Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

If you are in the hospital, this test may be repeated over 2 or 3 days. A significant rise or fall in the total CPK or CPK isoenzymes can help your health care provider diagnosis certain conditions.



How to prepare for the test:

Usually, no special preparation is necessary.

Tell your doctor about all the medications you are taking. Certain medications can interfere with test results. Drugs that can increase CPK measurements include the following:

  • Amphotericin B
  • Ampicillin
  • Some anesthetics
  • Anticoagulants
  • Aspirin
  • Clofibrate
  • Dexamethasone
  • Furosemide
  • Morphine
  • Alcohol
  • Cocaine


How the test will feel:

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.



Why the test is performed:

This test is done if a CPK test reveals that your total CPK level is elevated. CPK isoenzyme testing can help pinpoint the exact soure of the damaged tissue.

CPK is made of three slightly different substances:

  • CPK-1 (also called CPK-BB) is found mostly in the brain and lungs
  • CPK-2 (also called CPK-MB) is found mostly in the heart
  • CPK-3 (also called CPK-MM) is found mostly in skeletal muscle


Normal Values:



What abnormal results mean:

Higher-than-normal CPK-1 levels:

Because CPK-1 is found mostly in the brain and lungs, injury to either of these areas can increase CPK-1 levels. Increased CPK-1 levels may be due to:

Higher-than-normal CPK-2 levels:

CPK-2 levels rise 3 - 6 hours after a heart attack . If there is no further heart muscle damage, the level peaks at 12 - 24 hours and returns to normal 12 - 48 hours after tissue death.

Increased CPK-2 levels may also be due to:

  • Electrical injuries
  • Heart defibrillation (purposeful shocking of the heart by medical personnel)
  • Heart injury (for instance, from a car accident)
  • Inflammation of the heart muscle usually due to a virus (myocarditis)
  • Open heart surgery

CPK-2 levels do NOT usually rise with chest pain caused by angina , pulmonary embolism (blood clot in the lung), or congestive heart failure .

Higher-than-normal CPK-3 levels are usually a sign of muscle injury or muscle stress and may be due to:

  • Crush injuries
  • Muscle damage due to drugs or being immobile for a long time (rhabdomyolysis )
  • Muscular dystrophy
  • Myositis (skeletal muscle inflammation)
  • Receiving many intramuscular injections
  • Recent nerve and muscle function testing (electromyography)
  • Recent seizures
  • Recent surgery
  • Strenuous exercise


What the risks are:



Special considerations:

Factors that can affect test results include cardiac catheterization , intramuscular injections, recent surgery, and vigorous and prolonged exercise or immobilization.

Isoenzyme testing for specific conditions is about 90% accurate.



References:

Anderson JL. ST segment elevation acute myocardial infarction and complications of myocardial infarction. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 72.

Barohn RJ. Muscle diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 447.




Review Date: 2/19/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Find What You Need

Events
Careers
Foundation
About Us
Contact
Directions
News
Social Media Agreement
Joint Notice
Web Privacy Policy
WDH Staff Portal

Centers & Services

Cancer Center
Cardiovascular Care
Joint Replacement
Women & Children's
Physician Offices
Other Services

Conditions & Treatments

Health Library

Support Services

Support Groups
Care-Van
Dental Center
Social Work
Food & Nutrition
Integrative Wellness
Spiritual Care
Concerns & Grievances
Homecare and Hospice

For Patients

Pay Your Bill Online
Pricing Estimates
Financial Assistance
Interpreter Services
Surgery Preparation
Medical Record Request
Advance Directives
Clinical Research & Trials

For Healthcare Professionals

Work and Life
Financial Well-Being
Career and Growth

The Wentworth-Douglass Health System includes:

 

Address

Wentworth-Douglass Hospital
789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100