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Definition:

Therapeutic drug level are laboratory tests to look for the presence and the amount of specific drugs in the blood.



Alternative Names:

Therapeutic drug monitoring



How the test is performed:

Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.

Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.

Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.

See also: Venipuncture

The sample is then taken to the laboratory, where it is checked for the particular drug specified by your health care provider.



How to prepare for the test:

Some drug level tests require preparation. Your health care provider will tell you how to prepare.



How the test will feel:

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.



Why the test is performed:

With most medications, you need a certain level of drug in your bloodstream to obtain the desired effect. Some medications are harmful if the level rises too high and do not work if the levels are too low.

Monitoring the amount of the drug found in your blood allows your health care provider to make sure the drug levels are within an effective range.

Drug level testing is especially important in people taking drugs such as:

  • Procainamide or digoxin used to treat abnormal beating of the heart
  • Dilantin or valproic acid used to treat seizures
  • Gentamicin or amikacin, antibiotics used to treat infections

Testing may also be done to determine how well your body breaks down the drug (See: metabolism ), or how it interacts with other necessary drugs.



Normal Values:

Following are some of the drugs that are commonly checked, followed by the normal therapeutic levels:

  • Acetaminophen: varies with use
  • Amikacin: 15 to 25 mcg/mL
  • Aminophylline: 10 to 20 mcg/mL
  • Amitriptyline: 120 to 150 ng/mL
  • Carbamazepine: 5 to 12 mcg/mL
  • Chloramphenicol: 10 to 20 mcg/mL
  • Desipramine: 150 to 300 ng/mL
  • Digoxin: 0.8 to 2.0 ng/mL
  • Disopyramide: 2 to 5 mcg/mL
  • Ethosuximide: 40 to 100 mcg/mL
  • Flecainide: 0.2 to 1.0 mcg/mL
  • Gentamicin: 5 to 10 mcg/mL
  • Imipramine: 150 to 300 ng/mL
  • Kanamycin: 20 to 25 mcg/mL
  • Lidocaine: 1.5 to 5.0 mcg/mL
  • Lithium: 0.8 to 1.2 mEq/L
  • Methotrexate: greater than 0.01 mcmol
  • Nortriptyline: 50 to 150 ng/mL
  • Phenobarbital: 10 to 30 mcg/mL
  • Phenytoin: 10 to 20 mcg/mL
  • Primidone: 5 to 12 mcg/mL
  • Procainamide: 4 to 10 mcg/mL
  • Propranolol: 50 to 100 ng/mL
  • Quinidine: 2 to 5 mcg/mL
  • Salicylate: 100 to 250 mcg/mL
  • Theophylline: 10 to 20 mcg/mL
  • Tobramycin: 5 to 10 mcg/mL
  • Valproic acid: 50 to 100 mcg/mL

Note:

  • mcg/mL = microgram per milliliter
  • ng/mL = nanogram per milliliter
  • mEq/L = milliequivalents per liter
  • mcmol = micromole

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.



What abnormal results mean:

Following are toxic levels for some of the drugs that are commonly checked:

  • Acetaminophen: greater than 250 mcg/mL
  • Amikacin: greater than 25 mcg/mL
  • Aminophylline: greater than 20 mcg/mL
  • Amitriptyline: greater than 500 ng/mL
  • Carbamazepine: greater than 12 mcg/mL
  • Chloramphenicol: greater than 25 mcg/mL
  • Desipramine: greater than 500 ng/mL
  • Digoxin: greater than 2.4 ng/mL
  • Disopyramide: greater than 5 mcg/mL
  • Ethosuximide: greater than 100 mcg/mL
  • Flecainide: greater than 1.0 mcg/mL
  • Gentamicin: greater than 12 mcg/mL
  • Imipramine: greater than 500 ng/mL
  • Kanamycin: greater than 35 mcg/mL
  • Lidocaine: greater than 5 mcg/mL
  • Lithium: greater than 2.0 mEq/L
  • Methotrexate: greater than 10 mcmol over 24-hours
  • Nortriptyline: greater than 500 ng/mL
  • Phenobarbital: greater than 40 mcg/mL
  • Phenytoin: greater than 30 mcg/mL
  • Primidone: greater than 15 mcg/mL
  • Procainamide: greater than 16 mcg/mL
  • Propranolol: greater than 150 ng/mL
  • Quinidine: greater than 10 mcg/mL
  • Salicylate: greater than 300 mcg/mL
  • Theophylline: greater than 20 mcg/mL
  • Yobramycin: greater than 12 mcg/mL
  • Valproic acid: greater than 100 mcg/mL


What the risks are:

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)



Review Date: 8/28/2007
Reviewed By: Daniel R Alexander, MD, Department of Internal Medicine, St. Mary's Hospital, Leonardtown, MD. Review provided by VeriMed Healthcare Network.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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Phone: (603) 742-5252
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