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Digestive system
Digestive system


Liver cirrhosis, CT scan
Liver cirrhosis, CT scan


Clubbing
Clubbing


Digestive system organs
Digestive system organs


Definition:

Cirrhosis is scarring of the liver and poor liver function as a result of chronic liver disease .



Alternative Names:

Liver cirrhosis



Causes, incidence, and risk factors:

Cirrhosis is caused by chronic liver disease. Common causes of chronic liver disease in the U.S. include:

Other causes of cirrhosis include:



Symptoms:

Other symptoms that may occur with this disease:

Symptoms may develop gradually, or there may be no symptoms.



Signs and tests:

During a physical examination the health care provider may find:

  • An enlarged liver or spleen
  • Excess breast tissue
  • Excess fluid in the tissues lining the abdomen (ascites )
  • Expanded (distended) abdomen
  • Reddened palms
  • Red spider-like blood vessels on the skin
  • Smaller (contracted) fingers
  • Small testicles in men
  • Widened (dilated) veins in the abdomen wall
  • Yellow eyes or skin (jaundice)

Tests can reveal liver problems including:

A liver biopsy confirms cirrhosis.

This disease may also affect the results of the following tests:



Treatment:

Treatment attempts to manage the complications of cirrhosis and prevent further liver damage. It may include stopping certain medications and alcohol that caused the problem.

Other treatment options are available for the complications of cirrhosis:

  • Bleeding varices -- upper endoscopy with banding and sclerosis
  • Excess abdominal fluid (ascites) -- diuretics, restrict fluid and salt, and remove fluid (paracentesis)
  • Coagulopathy -- blood products or vitamin K
  • Encephalopathy -- lactulose medication and antibiotics
  • Infections -- antibiotics

If cirrhosis progresses and becomes life-threatening, a liver transplant should be considered.



Support Groups:

The stress of illness can often be eased by joining a support group whose members share common experiences and problems. See liver disease - support group .



Expectations (prognosis):

Cirrhosis is caused by irreversible scarring of the liver. Once cirrhosis develops, it is not possible to heal the liver or return its function to normal. It is a serious condition that can lead to many complications.

A liver specialist (hepatologist) should help evaluate and manage complications. Cirrhosis may result in the need for a liver transplant.



Complications:

A procedure called TIPS (transjugular intrahepatic portosystemic shunt) is sometimes necessary as a result of many of these complications.



Calling your health care provider:

Call your health care provider if:

  • You develop symptoms of cirrhosis

Call your provider, or go to the emergency room or call the local emergency number (such as 911) if:

  • You have rapid changes in alertness or consciousness
  • You vomit blood


Prevention:

Don't drink alcohol heavily. If you find that your drinking is getting out of hand, seek professional help.

Avoid intravenous drug use (or only use clean needles and never share other equipment) to reduce the risk of hepatitis B and C.

Some research indicates that hepatitis C may be spread via shared use of straws or items used to snort cocaine or other drugs. Avoid snorting drugs or sharing any related paraphernalia. If you have a problem with illicit drugs, seek help.



References:

Carithers RL, McClain C. Alcoholic Liver Disease. In: Feldman M, Friedman LS, Brandt LJ. Feldman: Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2006:chap 81.




Review Date: 12/12/2008
Reviewed By: A.D.A.M. Editorial Team: David Zieve, MD, MHA, Greg Juhn, MTPW, David R. Eltz. Previously reviewed by Christian Stone, MD, Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network (5/27/2008).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100