Wentworth-Douglass Hospital
(603) 742-5252
Decrease (-) Restore Default Increase (+) font size
Physicians
Site Search

Pulmonary aspergillosis
Pulmonary aspergillosis


Aspergillosis - chest X-ray
Aspergillosis - chest X-ray


Fungus
Fungus


Definition:

Invasive pulmonary aspergillosis is an infection of the lungs caused by a fungus.

See also: Allergic bronchopulmonary aspergillosis



Alternative Names:

Aspergillosis - acute invasive



Causes, incidence, and risk factors:

Aspergillosis is caused by the fungus aspergillus, which is commonly found in nature but only rarely causes illness in people.

Invasive pulmonary aspergillosis is the most serious type of aspergillosis infection. It can affect any organ, particularly the heart, lungs, brain, and kidneys.

People with a weakened immune system (for example, from chemotherapy or HIV ) are most likely to develop this kind of infection.

The most common type of immune system problem that causes this infection is a very low white blood cell count over a long period. People who have had chemotherapy or a bone marrow transplant sometimes have this type of problem.



Symptoms:
  • Chest pain
  • Cough
  • Fever
  • Joint pain
  • Shortness of breath
  • Unintentional weight loss


Signs and tests:

Listening to the chest with a stethoscope (auscultation ) may reveal crackles or a sound made by the inflamed lining of the lung rubbing against the lung (pleural friction rub).

Tests may include:



Treatment:

The goal of therapy is to treat any immune problems and to control the infection with antifungal medications. In the past, antifungal therapy involved a potentially harmful antibiotic called amphotericin B. Several less toxic drugs have been introduced that work against aspergillus.

If white blood cell counts are too low, the patient usually must reduce or stop immunosuppressive drug therapy and begin treatment with granulocyte-colony-stimulating factor (GCSF). This treatment stimulates the body's production of infection-fighting white blood cells.



Support Groups:



Expectations (prognosis):

Patients with the invasive form of pulmonary aspergillosis are usually critically ill. The disease is difficult to cure. Talk to your health care provider about your individual case.



Complications:

This infection can damage multiple organs, eventually causing multi-organ system failure.



Calling your health care provider:

Call your health care provider if you develop symptoms of this disorder. If you know you have a low white blood cell count and have fevers or symptoms of a respiratory infection, you should immediately tell your health care provider. An early diagnosis may improve the chance of a good outcome.



Prevention:

If your immune system isn't working properly because of disease or medications, tell your doctor right away if you see new symptoms.



References: Goldman L and Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders; 2007.


Review Date: 11/12/2007
Reviewed By: Andrew Schriber, M.D., F.C.C.P., Specialist in Pulmonary, Critical Care, and Sleep Medicine, Virtua Memorial Hospital, Mount Holly, New Jersey. Review provided by VeriMed Healthcare Network.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Find What You Need

Events
Careers
Foundation
About Us
Contact
Directions
News
Social Media Agreement
Joint Notice
Web Privacy Policy
WDH Staff Portal

Centers & Services

Cancer Center
Cardiovascular Care
Joint Replacement
Women & Children's
Physician Offices
Other Services

Conditions & Treatments

Health Information
Ebola Information

Support Services

Support Groups
Care-Van
Dental Center
Social Work
Food & Nutrition
Integrative Wellness
Spiritual Care
Concerns & Grievances
Homecare and Hospice

For Patients

Pay Your Bill Online
Pricing Estimates
Financial Assistance
Interpreter Services
Surgery Preparation
Medical Record Request
Advance Directives
Clinical Research & Trials

For Healthcare Professionals

Work and Life
Financial Well-Being
Career and Growth

The Wentworth-Douglass Health System includes:

 

Address

Wentworth-Douglass Hospital
789 Central Avenue, Dover, NH 03820
Phone: (603) 742-5252
Toll free: 1 (877) 201-7100